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Published on: February 27, 2018
Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction.
Zheping Chen1,2, Zhenxiang Zuo3, Yizheng Zhang2
1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
This bibliometric analysis reveals increasing research on neuroinflammation-induced postoperative cognitive dysfunction (POCD). Key areas include anesthesia and dexmedetomidine, with future trends focusing on apoptosis and epigenetic modifications.
Area of Science:
- Neuroscience
- Pharmacology
- Medical Informatics
Background:
- Postoperative cognitive dysfunction (POCD) is closely linked to neuroinflammation.
- Understanding this link is crucial for developing effective interventions.
- Bibliometric analysis offers insights into research trends and knowledge gaps.
Purpose of the Study:
- To analyze the research landscape of neuroinflammation-induced POCD.
- To identify key topics, influential publications, and leading institutions.
- To predict future research directions in this field.
Main Methods:
- Bibliometric analysis of publications from 2012-2023 in the Web of Science Core Collection.
- Utilized CiteSpace, VOSviewer, and R software for statistical and visual analysis.
- Keyword analysis and burst detection to identify trends and emerging topics.
Main Results:
- Research on neuroinflammation-induced POCD shows an upward trend.
- China leads in publications; Nanjing Medical University leads in collaborations.
- Dexmedetomidine emerged as a predominant research cluster; POCD was the most frequent keyword.
- Future trends include postoperative delirium (POD), perioperative neurocognitive disorders (PND), apoptosis, and epigenetic modifications.
Conclusions:
- Key research areas include anesthesia, surgery, dexmedetomidine, and the NLRP3 inflammasome.
- The mechanism of neuroinflammation-induced POCD is a central focus.
- Future research should explore POD, PND, apoptosis, and epigenetic modifications.
