Related Experiment Video
Updated: Jun 3, 2025

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
Improved Pulmonary Hypertension and Heart Failure by Diaphragmatic Plication and Tracheal Resection
Mitsuaki Kawashima1, Chihiro Konoeda1, Kazumichi Yamamoto1
1Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Abstract:
The patient was a 66-year-old man who developed exacerbation of respiratory and heart failure that necessitated tracheal intubation. The exacerbation was considered to be largely caused by asthma-chronic obstructive pulmonary disease overlap syndrome and type 3 pulmonary hypertension. However, left diaphragmatic eventration and tracheal stenosis were also found. We hypothesized that diaphragmatic eventration and tracheal stenosis surgeries would improve the patient's pulmonary function, pulmonary hypertension, and cardiac function. Postoperatively, he recovered well and was discharged home on room air, with a good performance status. He also showed improved pulmonary hypertension on echocardiography and improved pulmonary function test results.
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