Prognostic factors for first recurrence following meningioma surgery
Related Experiment Video
Updated: Jun 3, 2025
Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
Published on: February 24, 2023
George Fotakopoulos1, Vasiliki Epameinondas Georgakopoulou2, Demetrios A Spandidos3
1Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece.
Abstract:
The present study investigated the role of the Simpson grade system, MIB-1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded. After applying the exclusion criteria, 103 patients were included in the study. Following a mean follow-up period of 67.3±33 months, there were 12 cases (11.6%) of tumor recurrence. No significant association between meningioma recurrence and age, sex, or tumor location was found. When comparing the risk of recurrence between Simpson grades I, II, III and IV excisions, and between Simpson grade V, the difference was statistically significant. When comparing WHO grade I and II meningioma vs. grade III, the difference was significant. MIB-1 LI >3% exhibited a trend towards a significant association with the risk of recurrence. On the whole, the present study demonstrates that the Simpson grade is associated with the risk of recurrence. Patients with tumors with an MIB-1 index >3% may also be at a risk of recurrence. Notably, the present study proposed that in the case of recurrence, this is more likely to occur in an interval of 5.5 years following surgical intervention.
Insights
The Simpson grade system significantly impacts meningioma recurrence risk. Higher MIB-1 labeling index (>3%) may also predict recurrence, often occurring 5.5 years post-surgery.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Meningiomas are primary brain tumors with varying recurrence rates.
- Predicting meningioma recurrence is crucial for patient management and follow-up strategies.
Purpose of the Study:
- To investigate the association between Simpson grade, MIB-1 labeling index, and meningioma recurrence.
- To identify prognostic factors for predicting tumor recurrence after surgical resection.
Main Methods:
- Retrospective evaluation of 103 patients who underwent craniotomy for meningioma resection (2008-2018).
- Exclusion of patients with neurofibromatosis, acoustic neurinomas, or prior radiation therapy.
- Analysis of recurrence rates based on Simpson grade, WHO grade, MIB-1 labeling index, and clinical factors.
Main Results:
- Tumor recurrence was observed in 11.6% of patients over a mean follow-up of 67.3 months.
- A statistically significant association was found between Simpson grades and recurrence risk.
- WHO grade III meningiomas showed a significant difference in recurrence compared to grades I and II.
- MIB-1 labeling index >3% showed a trend towards significant association with recurrence.
Conclusions:
- The Simpson grade is a significant predictor of meningioma recurrence.
- Elevated MIB-1 labeling index (>3%) may indicate an increased risk of recurrence.
- Recurrence is most likely to occur approximately 5.5 years after surgical intervention.
