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GFR Estimation and Correlation for Oncology Patients by Two Methods, Gates Method and Dual Time Point Plasma Sampling
Sachin Tayal1, Varun Shukla1, Manikandan Venkatachalam1
1Department of Nuclear Medicine and Molecular Imaging, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Varanasi, India.
Background:
With the increasing number of oncology cases and a parallel surge in chemotherapeutic drugs for treatment, the treating physicians conducts nephrotoxicity evaluation to provide a personalized dosing strategy. Of the various tests available, glomerular filtration rate (GFR) under gamma camera with help of Gates method has gained importance, being a good index of overall kidney functions. In addition to this, there has been an alternate and old method for GFR estimation: plasma sampling. We at our Institution conducted both the methods for better evaluation of GFR in cancer patient management.
Aim:
Comparison of Gates' camera based GFR based on kidney depth correction using Tonessen's method and CT based manual depth calculation with dual time point plasma sampling in cancer patients.
Method:
A retrospective study wherein patients' database were evaluated over a period of four months after approval from our Institutional Review Board. Thirty patients were included in the study. GFR was evaluated by two methods: Gates camera based and dual time plasma sampling method. Statistical analysis was done to help evaluate a correlation coefficient between the methods (Gates' method with and without CT based manual depth correction and dual time point plasma sampling).
Results:
Our study showed moderate correlation between Gates' camera based GFR and dual time plasma sampling method.
Conclusion:
One need to understand the limitation of each method and see if the renal depth corrections can be done with the help of CT or lateral images of NM for near accurate GFR and in case of selecting dual plasma sampling, errors to be minimized in pipetting and sample counting. Hence, it will be better to use both the methods for coming to a conclusion.
Insights
This study compared two methods for estimating kidney function in cancer patients: Gates camera imaging and plasma sampling. Both methods showed a moderate correlation, suggesting combined use for accurate personalized dosing.
Area of Science:
- Nephrology
- Nuclear Medicine
- Oncology
Background:
- Increasing cancer cases and chemotherapy necessitate accurate kidney function evaluation for personalized dosing.
- Glomerular filtration rate (GFR) is a key indicator of kidney function.
- Gates method (gamma camera) and plasma sampling are used for GFR estimation.
Purpose of the Study:
- To compare Gates camera-based GFR with dual time-point plasma sampling in cancer patients.
- To evaluate GFR estimation using Gates method with CT-based depth correction versus plasma sampling.
Main Methods:
- Retrospective study of 30 cancer patients over four months.
- GFR assessed using Gates camera method (with and without CT depth correction) and dual time plasma sampling.
- Statistical analysis to determine correlation coefficients between methods.
Main Results:
- A moderate correlation was observed between Gates camera-based GFR and dual time plasma sampling.
- CT-based depth correction may improve accuracy of Gates method.
Conclusions:
- Both Gates camera and plasma sampling methods have limitations for GFR estimation.
- Utilizing both methods, potentially with CT-assisted depth correction, may enhance accuracy in cancer patient management.
