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GFR Estimation and Correlation for Oncology Patients by Two Methods, Gates Method and Dual Time Point Plasma Sampling
Sachin Tayal1, Varun Shukla1, Manikandan Venkatachalam1
1Department of Nuclear Medicine and Molecular Imaging, Homi Bhabha Cancer Hospital and Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Varanasi, India.
Summary
This study compared two methods for estimating kidney function in cancer patients: Gates camera imaging and plasma sampling. Both methods showed a moderate correlation, suggesting combined use for accurate personalized dosing.
Area of Science:
- Nephrology
- Nuclear Medicine
- Oncology
Background:
- Increasing cancer cases and chemotherapy necessitate accurate kidney function evaluation for personalized dosing.
- Glomerular filtration rate (GFR) is a key indicator of kidney function.
- Gates method (gamma camera) and plasma sampling are used for GFR estimation.
Purpose of the Study:
- To compare Gates camera-based GFR with dual time-point plasma sampling in cancer patients.
- To evaluate GFR estimation using Gates method with CT-based depth correction versus plasma sampling.
Main Methods:
- Retrospective study of 30 cancer patients over four months.
- GFR assessed using Gates camera method (with and without CT depth correction) and dual time plasma sampling.
- Statistical analysis to determine correlation coefficients between methods.
Main Results:
- A moderate correlation was observed between Gates camera-based GFR and dual time plasma sampling.
- CT-based depth correction may improve accuracy of Gates method.
Conclusions:
- Both Gates camera and plasma sampling methods have limitations for GFR estimation.
- Utilizing both methods, potentially with CT-assisted depth correction, may enhance accuracy in cancer patient management.
