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Updated: Jun 3, 2025

Identification of Kinase-substrate Pairs Using High Throughput Screening
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FAM20C: A key protein kinase in multiple diseases

Rui Zhang1, Yanming Ren1, Yan Ju1

  • 1Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Genes & Diseases
|January 10, 2025
PubMed

Insights

Family with sequence similarity 20 C (FAM20C) is a Golgi kinase crucial for phosphorylating secreted proteins. Understanding FAM20C

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase.
  • FAM20C phosphorylates secreted proteins, impacting biological processes like cancer progression and biomineralization.
  • Dysregulation of FAM20C is implicated in various diseases, including cancers, bone/tooth mineralization disorders, cardiovascular diseases, and metabolic disorders.

Purpose of the Study:

  • To comprehensively review the literature on FAM20C structure and function.
  • To highlight FAM20C's role in disease pathogenesis.
  • To explore FAM20C as a potential therapeutic target.

Main Methods:

  • Literature review of existing studies on FAM20C.
  • Analysis of FAM20C's molecular mechanisms.
  • Correlation of FAM20C activity with disease development.

Main Results:

  • FAM20C's kinase activity is essential for post-translational modification of numerous secreted proteins.
  • FAM20C plays a significant role in cancer cell growth, invasion, and metastasis.
  • FAM20C is critical for proper biomineralization of teeth and bone.
  • FAM20C is linked to cardiovascular and endocrine-metabolism disorders.

Conclusions:

  • FAM20C is a key regulator of secreted protein function and a significant factor in multiple disease states.
  • Targeting FAM20C may offer novel therapeutic strategies for cancer and other diseases.
  • Further research into FAM20C's disease-specific mechanisms is warranted.
Keywords:
Biological functionsBiomineralizationCancer progressionFAM20CProtein phosphorylation

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