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Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
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FAM20C: A key protein kinase in multiple diseases
Rui Zhang1, Yanming Ren1, Yan Ju1
1Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Genes & Diseases
|January 10, 2025
Summary
Family with sequence similarity 20 C (FAM20C) is a Golgi kinase crucial for phosphorylating secreted proteins. Understanding FAM20C
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase.
- FAM20C phosphorylates secreted proteins, impacting biological processes like cancer progression and biomineralization.
- Dysregulation of FAM20C is implicated in various diseases, including cancers, bone/tooth mineralization disorders, cardiovascular diseases, and metabolic disorders.
Purpose of the Study:
- To comprehensively review the literature on FAM20C structure and function.
- To highlight FAM20C's role in disease pathogenesis.
- To explore FAM20C as a potential therapeutic target.
Main Methods:
- Literature review of existing studies on FAM20C.
- Analysis of FAM20C's molecular mechanisms.
- Correlation of FAM20C activity with disease development.
Main Results:
- FAM20C's kinase activity is essential for post-translational modification of numerous secreted proteins.
- FAM20C plays a significant role in cancer cell growth, invasion, and metastasis.
- FAM20C is critical for proper biomineralization of teeth and bone.
- FAM20C is linked to cardiovascular and endocrine-metabolism disorders.
Conclusions:
- FAM20C is a key regulator of secreted protein function and a significant factor in multiple disease states.
- Targeting FAM20C may offer novel therapeutic strategies for cancer and other diseases.
- Further research into FAM20C's disease-specific mechanisms is warranted.
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