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Related Experiment Video

Updated: Jul 11, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Accelerated Low-Dose Total Skin Electron Beam Therapy Using the Modified Stanford Technique: An In Vivo Dosimetry

Omar El Fadel1, Leland Damron1, Christian Fernandez1

  • 1Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, USA.

Cureus
|January 10, 2025
PubMed
Summary

Accelerated low-dose total skin electron beam therapy (LD-TSEBT) with the modified Stanford technique (mST) delivers accurate doses for mycosis fungoides (MF). In vivo dosimetry using OSLDs confirms most patients meet homogeneity criteria, supporting this condensed treatment approach.

Keywords:
cutaneous t cell lymphomas (ctcl)modified stanford techniquemycosis fungoidesoptically stimulated radiation dosimeterstotal skin electron beam therapy

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Last Updated: Jul 11, 2026

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Radiation Oncology
  • Dermatology
  • Medical Physics

Background:

  • Low-dose total skin electron beam therapy (LD-TSEBT) is increasingly used for mycosis fungoides (MF) due to lower toxicity and good efficacy.
  • Accelerated LD-TSEBT with the modified Stanford technique (mST) offers a more convenient treatment schedule.
  • Limited in vivo dosimetry data exists to validate the accuracy of accelerated LD-TSEBT using the mST.

Purpose of the Study:

  • To retrospectively analyze in vivo dosimetry data for patients with MF treated with accelerated LD-TSEBT using the mST.
  • To assess the dose homogeneity and accuracy of this condensed treatment regimen.

Main Methods:

  • Retrospective analysis of 36 patients with MF treated with accelerated LD-TSEBT (mST).
  • In vivo dosimetry performed using optically stimulated radiation dosimeters (OSLDs) at 10 anatomical sites.
  • Dose measurements compared to prescribed dose using European Organisation For Research And Treatment Of Cancer (EORTC) homogeneity criteria (±20% of prescribed dose).

Main Results:

  • A total of 360 OSLD measurements were collected, with a median relative dose of 97.4% across all sites.
  • 85.8% of measurements met EORTC homogeneity criteria at most sites, with variations noted at specific locations like the left dorsal hand.
  • Patient metrics (height, BMI) did not significantly affect delivered dose or adherence to homogeneity criteria.

Conclusions:

  • Accelerated LD-TSEBT using the mST effectively delivers accurate radiation doses for MF treatment.
  • The majority of patients met established homogeneity criteria, validating the mST approach.
  • OSLDs are suitable for in vivo dosimetry in this regimen, ensuring treatment adequacy despite accelerated cycling.