Testing the mediating mechanism of alcohol use on the association between retirement and depressive symptoms in the United States using generalized mixed effect models
Related Experiment Video
Updated: Jun 3, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Antonia Diaz-Valdes1,2,3,4, Christina M Sellers5, José T Medina3,6
1Society and Health Research Center, Health and Society Research Center, Universidad Mayor Chile, Las Condes Santiago, Chile.
Objectives:
Both alcohol use and the prevalence of depression-depressive disorders, among older adults have increased over the past several decades and have been associated with increased morbidity and mortality. To our knowledge, the interactions between retirement, depression, and alcohol use have not yet been examined. This study aims to longitudinally explore the mediating role of alcohol use on the association between retirement and depressive symptoms in the United States, comparing individuals who are retired and not retired, while also exploring individuals who transitioned into and out of retirement at different times.
Method:
Data from the Health and Retirement Study (waves 1994 to 2020) were used. Respondents aged 50 years and older who had valid information on retirement status and had observations for at least 3 waves were included in our sample (n = 27,575; nt = 193,642). A generalized longitudinal mixed-effect model was conducted on depressive symptoms (CESD-8). Direct, indirect, and total effects were calculated to test the mediating mechanism of alcohol use.
Results:
Retirement was associated with increased depressive symptoms (b = 0.04, p < 0.05), while moderate alcohol use was associated with decreased depressive symptoms (b = -0.09, p < 0.05), and binge drinking was associated with increased depressive symptoms (b = 0.06, p < 0.05). Alcohol played a mediating role in the association between retirement and depressive symptoms, with moderate use serving as a protective factor.
Conclusion:
Screening and treating depression and alcohol misuse among older adults is key to promoting longer and healthier lives. Providing alternative coping mechanisms to heavy alcohol consumption for retirees is crucial.
More Related Videos
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
08:05A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
Published on: January 5, 2018
Related Concept Videos
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
CNS Depressants: Alcohol and Nicotine
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Stress Prevention and Stress Management Techniques IV