The Impact of Injectable Platelet-rich Fibrin on Orthodontic Tooth Movement during Retraction: A Randomized...

Area of Science:

• Orthodontics
• Regenerative Dentistry
• Biomaterials

Background:

• Orthodontic treatment involves tooth movement and space closure.
• Controlling the rate of tooth movement and anchorage is crucial for treatment efficiency.
• Injectable platelet-rich fibrin (i-PRF) is a biomaterial with potential regenerative properties.

Purpose of the Study:

• To evaluate the effect of i-PRF on space closure rates during orthodontic retraction.
• To assess the impact of i-PRF on anchor loss during orthodontic retraction.
• To determine the safety and efficacy of i-PRF as an adjunct in orthodontic treatment.

Main Methods:

• A randomized controlled trial involving 24 participants with malocclusion requiring extractions.
• Participants were divided into an experimental group receiving i-PRF and a control group.
• Measurements of space closure and anchor loss were recorded at baseline and at 3, 6, and 9 weeks.
• Statistical analysis included Mann-Whitney and independent Student's t-tests.

Main Results:

• The i-PRF group demonstrated accelerated space closure in both maxillary and mandibular arches compared to the control group.
• Statistically significant acceleration in space closure was observed in the maxilla at 6 and 9 weeks, and in the mandible at 6 weeks.
• No statistically significant differences in anchor loss were found between the i-PRF and control groups in either arch.

Conclusions:

• i-PRF enhances the rate of orthodontic space closure, potentially reducing overall treatment time.
• i-PRF can be safely used as an adjunct in orthodontic treatment without negatively impacting anchorage stability.
• The findings suggest i-PRF is a promising biomaterial for optimizing orthodontic treatment outcomes.