A novel hollow-core antiresonant fiber-based biosensor for blood component detection in the THz regime

This article proposes a novel biosensor based on a five-semi-circular cladding tube hollow core antiresonant fiber (HC-ARF) with a frequency range of 0.5-2.8 THz, using Zeonex as the background material. The HC-ARF biosensor analyses various blood components, namely water, plasma, white blood cells (WBC), hemoglobin (HB), and red blood cells (RBC). We utilized COMSOL Multiphysics to perform the numerical analysis of the sensor model. For water, plasma, WBC, HB, and RBC, the proposed HC-ARF biosensor exhibits the highest sensitivity levels of 99.50%, 99.58%, 99.43%, 99.58%, and 99.46%, respectively. Furthermore, it demonstrates confinement loss (CL) and effective material loss (EML) of 1.3  × 10^-3dBcm^-1and 5.3  × 10^-5dBcm^-1, respectively.