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Published on: April 17, 2020
Prospective Evaluation of Opioid Cessation in Patients With Suspected Opioid-Induced Esophageal Dysfunction
A Ezquerra-Durán1, L Alcalá-González2,3, I K Araujo1
1Neurogastroenterology and Motility Unit, Gastroenterology Department, Institut Clínic de Malalties Digestives i Metabòliques (ICMDM), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Introduction:
The causal relationship between chronic opioid use and esophageal motor dysfunction in symptomatic patients has not been established.
Methods:
A prospective before-and-after multicenter study, including chronic active opioid patients referred for esophageal motility tests because of nonobstructive dysphagia.
Results:
Thirty-seven patients were evaluated, and 27 (73%) had criteria for opioid-induced esophageal dysfunction. In 19 patients who discontinued opioids for at least 7 days, esophageal motor disorders resolved in 10 (52.6%), accompanied by a clinical success response (defined as Eckardt ≤3) in 64.3%.
Discussion:
Discontinuation of opioids is associated with clinical and esophageal motility improvement in up to half of the patients.
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