Related Experiment Video
Updated: Jun 3, 2025
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
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The Hippo Signaling Pathway Manipulates Cellular Senescence
Chiharu Miyajima1, Mai Nagasaka1,2, Hiromasa Aoki3
1Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Cells
|January 10, 2025
Summary
The Hippo pathway regulates cell growth and homeostasis. This review explores its link to cellular senescence and aging, offering insights for tissue regeneration and anti-aging therapies.
Area of Science:
- Cellular Biology
- Molecular Biology
- Gerontology
Background:
- The Hippo pathway is a critical regulator of cell proliferation, apoptosis, and tissue homeostasis.
- Aberrant Hippo pathway signaling is implicated in various diseases, including cancer and immune disorders.
- Cellular senescence is a stress-induced state of cell cycle arrest that protects against damage but contributes to aging when accumulated.
Purpose of the Study:
- To review the intricate relationship between the Hippo pathway and cellular senescence.
- To elucidate the mechanisms linking the Hippo pathway to aging and age-related diseases.
- To explore potential therapeutic applications for tissue regeneration and rejuvenation.
Main Methods:
- Literature review of recent studies on the Hippo pathway and cellular senescence.
- Analysis of molecular mechanisms connecting Hippo signaling to aging processes.
- Synthesis of findings related to therapeutic interventions.
Main Results:
- A significant correlation exists between Hippo pathway activity and cellular senescence.
- The Hippo pathway influences key processes in aging and age-related disease development.
- Emerging evidence suggests the Hippo pathway's role in maintaining tissue homeostasis during aging.
Conclusions:
- The Hippo pathway and cellular senescence are closely intertwined, impacting tissue homeostasis and aging.
- Understanding this crosstalk offers novel therapeutic targets for age-related diseases.
- Further research may unlock strategies for tissue regeneration and promote healthy aging.
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