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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Molecular testing and precision oncology: An overview.

Melissa Styan Burkett1

  • 1Melissa Styan Burkett is a CRNP at the UPMC Hillman Cancer Center in Monroeville, Pa.

Nursing
|January 10, 2025
PubMed
Summary

Targeted cancer therapy uses DNA insights for treatment. This review covers genetic testing, biomarkers, and nursing roles in precision oncology.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cancer treatment is evolving with molecular insights.
  • Targeted therapy offers personalized treatment options.

Purpose of the Study:

  • Provide an overview of targeted therapy in cancer.
  • Discuss next-generation sequencing and genetic alterations.
  • Review circulating tumor DNA testing and its applications.

Main Methods:

  • Literature review of targeted therapy advancements.
  • Explanation of genomic testing principles.
  • Analysis of circulating tumor DNA (ctDNA) applications.

Main Results:

  • Next-generation sequencing identifies genetic alterations.

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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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  • Biomarkers guide targeted therapy selection.
  • ctDNA testing aids in treatment monitoring and selection.

    • Conclusions:

    • Genomic testing is crucial for personalized cancer care.
    • Targeted therapies show promise for various cancer types.
    • Understanding genomic reports is vital for clinical practice and nursing.