CMCS-PVA@CA hydrogel dressing: A promoter of wound healing with MRSA virulence attenuation function

Traditional wound dressings, primarily centered on antimicrobial or bactericidal strategies, have inadvertently contributed to the rise of drug-resistant bacterial colonies at wound sites, thus prolonging the healing process. In this study, we developed an innovative hydrogel dressing, CMCS-PVA@CA, incorporating carboxymethyl chitosan (CMCS), polyvinyl alcohol (PVA), and cichoric acid (CA), specifically designed to treat skin wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). Computational biology analyses reveal that CA exerts substantial anti-virulence activity by targeting serine/threonine phosphatase (Stp1), achieving an IC₅₀ of 3.912 μM, thereby mitigating MRSA pathogenicity. Notably, CA lacks intrinsic antibacterial properties, minimizing the risk of fostering drug resistance. Furthermore, CMCS-PVA@CA demonstrates effective wound healing acceleration and meets clinical application standards, with its robust mechanical properties enhancing patient comfort. In essence, this study presents CMCS-PVA@CA as a promising hydrogel dressing offering a viable solution for treating drug-resistant bacterial infections in skin wounds.