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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Teeth01:15

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Assessment of the Mouth01:26

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A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
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Healthcare Associated Infections II: Preventive Measures01:22

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
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Dent disease: clinical practice recommendations.

Arend Bökenkamp1, Gema Ariceta2, Detlef Böckenhauer3,4

  • 1Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 10, 2025
PubMed
Summary
This summary is machine-generated.

Dent disease is a rare X-linked tubulopathy causing kidney problems like stones and failure. This summary provides essential guidance for diagnosing and managing this condition.

Keywords:
guidelinesnephrolithiasisproteinuriaproximal tubulesystematic review

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Area of Science:

  • Nephrology
  • Genetics
  • Rare Diseases

Background:

  • Dent disease is a rare X-linked tubulopathy.
  • Characterized by low-molecular-weight proteinuria and hypercalciuria.
  • Can lead to nephrolithiasis, nephrocalcinosis, and kidney failure.

Purpose of the Study:

  • To summarize current knowledge on Dent disease.
  • To provide clinical practice recommendations for diagnosis and management.
  • To address diagnostic delays caused by nephrotic-range proteinuria.

Main Methods:

  • Systematic literature search.
  • Delphi procedure among stakeholders.
  • Endorsement by ERA and ESPN working groups.

Main Results:

  • Dent disease presents with proximal tubular dysfunction.
  • Kidney failure occurs in 30%-80% of affected males between ages 30-50.
  • Nephrotic-range proteinuria can mimic other conditions, causing diagnostic delays.

Conclusions:

  • Clinical practice recommendations are crucial due to the rarity of Dent disease.
  • Evidence-based guidance is needed for timely diagnosis and effective management.
  • Collaboration among experts ensures comprehensive recommendations for Dent disease care.