Related Experiment Video
Updated: Jun 3, 2025

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity
Published on: May 7, 2017
The cranium from the Octagon in Ephesos
Gerhard W Weber1,2, Petra G Šimková3,4, Daniel M Fernandes4,5
1Department of Evolutionary Anthropology, University of Vienna, Djerassiplatz 1, A-1030, Vienna, Austria. gerhard.weber@univie.ac.at.
Archaeologists identified a skeleton from Ephesos using advanced genetic and dating methods. The remains belong to a young boy, not Arsinoë IV, with Italian or Sardinian ancestry, dating between 205-36 BC.
Area of Science:
- Bioarchaeology
- Ancient Genetics
- Radiocarbon Dating
Background:
- A well-preserved skeleton was discovered in Ephesos in 1929, sparking speculation about its identity, with a prominent theory suggesting it belonged to Arsinoë IV.
- Arsinoë IV, daughter of Ptolemy XII and sister of Cleopatra VII, was reportedly killed in Ephesos in 41 BC.
Purpose of the Study:
- To determine the identity and origin of the skeleton found in the Octagon at Ephesos.
- To resolve the long-standing archaeological debate regarding the skeleton's potential connection to Arsinoë IV.
Main Methods:
- State-of-the-art morphological, genetic, and radiocarbon (14C) dating analyses were performed on the cranium and bone samples (femur, rib).
- Genetic analyses confirmed the cranium and femur belonged to the same individual.
- 14C dating provided a date range for the cranium.
Main Results:
- Genetic analyses confirmed the cranium and femur belong to the same individual.
- 14C dating of the cranium yielded a date range of 205–36 BC.
- The individual was identified as a male, excluding the possibility of it being Arsinoë IV.
- The boy was 11–14 years old and exhibited significant developmental disturbances.
- Genetic ancestry analysis suggested origins from the Italian peninsula or Sardinia.
Conclusions:
- The skeleton is definitively not Arsinoë IV, but rather a young boy of likely Italian or Sardinian descent who lived between 205–36 BC.
- The findings allow for new avenues of research into the boy's life, social background, and fate.
- The actual burial place and fate of Arsinoë IV in Ephesos remain undetermined.
Related Concept Videos
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Cerebrum: Anatomical Overview I
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

