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Updated: Jun 3, 2025
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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Prevalence and Risk Factors of Cognitive Impairment in COPD: A Systematic Review and Meta-Analysis
Ziwei Zhang1,2, Pengyu Yang3, Gui Xiao4
1Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, China.
Public Health Nursing (Boston, Mass.)
|January 11, 2025
Summary
Cognitive impairment (CI) affects 20-30% of patients with chronic obstructive pulmonary disease (COPD). Key risk factors include cough, FEV1, age, and depression, highlighting the need for early screening and intervention in COPD management.
Area of Science:
- Pulmonary Medicine
- Neurology
- Epidemiology
Background:
- Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that can affect multiple organs.
- Hypoxia in COPD is linked to cognitive impairment (CI), a condition often overlooked in clinical assessments.
- Mild cognitive impairment (MCI) may precede dementia and represents a potential window for intervention.
Purpose of the Study:
- To systematically review and meta-analyze the pooled prevalence of cognitive impairment (CI) and mild cognitive impairment (MCI) in patients with COPD.
- To identify and evaluate the key risk factors associated with the development of CI in the COPD population.
Main Methods:
- A comprehensive systematic review and meta-analysis of cohort, case-control, and cross-sectional studies.
- Searched major databases (PubMed, Web of Science, Cochrane Library, etc.) up to June 2023.
- Employed random-effects models for prevalence and risk factor estimation, with quality assessed by NOS and AHRQ criteria.
Main Results:
- Included 41 studies with 138,030 participants; pooled prevalence of CI was 20-30% and MCI was 24%.
- Significant heterogeneity was observed (I² > 90%), with geographical region identified as a source.
- Identified influential factors for CI in COPD: cough, FEV1, PaO₂, age, education, depression, and BODE index.
Conclusions:
- The prevalence of CI in COPD patients shows an increasing trend, varying by region and assessment tools.
- Specific factors like cough, lung function (FEV1), oxygen levels (PaO₂), age, education, depression, and BODE index significantly influence CI development.
- Recommends early screening and targeted interventions for CI in COPD patients to mitigate incidence and improve outcomes.
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