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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

295
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
295
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

305
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
305

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Updated: Jun 3, 2025

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
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Advances in Surface-Enhanced Raman Spectroscopy for Therapeutic Drug Monitoring.

Huasheng Lai1, Xinlan Wang1, Menghan Qi1

  • 1Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Molecules (Basel, Switzerland)
|January 11, 2025
PubMed
Summary
This summary is machine-generated.

Surface-enhanced Raman spectroscopy (SERS) offers a sensitive, cost-effective method for therapeutic drug monitoring (TDM). Advancements in SERS substrates and techniques address challenges, improving personalized medicine and patient outcomes.

Keywords:
analytical strategiesenhancement substratesurface-enhanced Raman spectroscopytherapeutic drug monitoring

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Spectroscopy

Background:

  • Therapeutic drug monitoring (TDM) is crucial for optimizing drug dosages, especially for narrow therapeutic index drugs.
  • Surface-enhanced Raman spectroscopy (SERS) presents a highly sensitive, non-destructive analytical technique with potential for TDM.

Purpose of the Study:

  • To review the latest advancements in SERS substrates and their applications for TDM.
  • To discuss challenges and innovative solutions for SERS in TDM.

Main Methods:

  • Review of recent literature on SERS substrates and TDM applications.
  • Analysis of emerging techniques addressing SERS limitations in biological sample analysis.

Main Results:

  • Innovations in SERS substrate design enhance detection sensitivity and selectivity for TDM.
  • Digital SERS, microfluidic SERS, and machine learning-based approaches offer solutions to reproducibility and matrix interference issues.

Conclusions:

  • SERS is a rapidly developing technology with significant potential for improving TDM.
  • Integration of SERS with new technologies promises to advance personalized medicine and patient care.