Quinolin-4-ones: Methods of Synthesis and Application in Medicine

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Pharmacology

Background:

• Quinolinones (quinolones) are heterocyclic compounds found naturally and synthesized. They have a long history of use as antibiotics.
• Recent research highlights their antiproliferative effects, expanding their therapeutic potential.

Purpose of the Study:

• To review synthetic methodologies for quinolin-4-ones.
• To provide an overview of quinolin-4-one structures, their evolution, and structure-activity relationships.

Main Methods:

• Literature review of synthetic routes to quinolin-4-ones.
• Analysis of structural diversity and biological activities.

Main Results:

• Numerous synthetic methods for quinolin-4-ones have been developed since the late 19th century.
• Quinolinone analogs exhibit a wide range of biological activities, including antibiotic and antiproliferative properties.

Conclusions:

• Synthetic advancements allow for the creation of diverse quinolinone analogs.
• Quinolinones are promising scaffolds for developing new therapeutic agents, particularly for cancer treatment.