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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular

Yoong Mond Teh1, Siti Aisyah Mualif1, Nur Izzati Mohd Noh2

  • 1Department of Biomedical Engineering and Health Science, Faculty of Electrical Engineering, University Technology Malaysia (UTM), Johor Bahru 81310, Malaysia.

International Journal of Molecular Sciences
|January 11, 2025
PubMed

Insights

Traditional Chinese Medicine (TCM) offers natural products as a complementary therapy for chronic kidney disease (CKD). These products may target cellular senescence and autophagy to slow CKD progression and reduce adverse effects.

Area of Science:

  • Nephrology
  • Pharmacology
  • Gerontology

Background:

  • Chronic kidney disease (CKD) is a progressive condition with no cure, often linked to premature aging.
  • Current treatments focus on managing progression and protecting kidneys, but alternative therapies are sought.
  • Autophagy and cellular senescence are implicated in aging and CKD, presenting therapeutic targets.

Purpose of the Study:

  • To review natural products used in Traditional Chinese Medicine (TCM) for CKD treatment.
  • To explore the mechanisms of TCM natural products targeting autophagy and cellular senescence in CKD.
  • To assess the potential of TCM as a complementary therapy for CKD.

Main Methods:

  • Literature review of studies on TCM natural products and CKD.
  • Analysis of active ingredients and their effects on renoprotection.
  • Examination of impacts on autophagy and cellular senescence pathways.

Main Results:

  • TCM natural products show potential for renoprotection in CKD.
  • Evidence suggests these products can modulate autophagy and cellular senescence.
  • Limited research exists on synergistic effects and comprehensive clinical validation.

Conclusions:

  • Natural products in TCM may offer a renoprotective, complementary approach to CKD management.
  • Targeting autophagy and cellular senescence with TCM is a promising avenue for slowing CKD progression.
  • Further clinical and molecular research is needed to validate efficacy and understand synergistic actions.
Keywords:
autophagycellular senescencechronic kidney diseasenatural productrenoprotectivetraditional Chinese medicine

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