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Updated: Jun 3, 2025

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Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
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Special Issue "New Molecular Insights into Ischemia/Reperfusion"
1Department of Physical Therapy, College of Health Science, Youngsan University, Yangsan 50510, Republic of Korea.
International Journal of Molecular Sciences
|January 11, 2025
Summary
Ischemia/reperfusion (IR) injury worsens tissue damage when blood flow is restored. Understanding this complex process is crucial for developing effective treatments to mitigate IR injury.
Area of Science:
- Cardiovascular Science
- Pathophysiology
- Translational Medicine
Background:
- Ischemia/reperfusion (IR) injury is a significant clinical challenge.
- Restoration of blood flow to ischemic tissues paradoxically causes further damage and cell death.
- IR injury contributes to organ damage in various clinical settings, including stroke, myocardial infarction, and transplantation.
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