Antiproliferative Mechanisms of Metformin in Breast Cancer: A Systematic Review of the Literature

Area of Science:

• Oncology
• Pharmacology

Background:

• Metformin, a common antidiabetic medication, exhibits potential antiproliferative effects against various cancers, including breast cancer.
• The precise molecular mechanisms underlying metformin's anti-cancer activity are not fully elucidated.
• Understanding these mechanisms is crucial for exploring metformin's therapeutic potential in oncology.

Approach:

• This study conducted a systematic review of seventeen research articles.
• The review focused on identifying and synthesizing reported mechanisms of metformin's antiproliferative action against breast cancer.
• Literature analysis aimed to consolidate current knowledge on metformin's anti-cancer effects.

Key Points:

• The majority of reviewed studies confirm metformin's antiproliferative potential in breast cancer models.
• Multiple and varied mechanisms contribute to metformin's anti-cancer effects.
• Factors influencing metformin's efficacy in cancer treatment require further investigation.

Conclusions:

• Metformin demonstrates a confirmed antiproliferative capacity against breast cancer.
• The diverse mechanisms of action highlight the complexity of metformin's role in cancer.
• Further investigation is warranted to fully leverage metformin as a potential anti-cancer therapeutic agent.