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Updated: Jun 3, 2025

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Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities

Ye-Jin Hwang1,2, Moon Jong Kim1,2

  • 1Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea.

International Journal of Molecular Sciences
|January 11, 2025
PubMed

Insights

The DREAM complex regulates cell cycle and quiescence. Understanding its role in cancer and developing targeted therapies could offer new treatment options.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The DREAM complex (dimerization partner, RB-like, E2F, and multi-vulval class B) is a conserved transcriptional repressor.
  • It regulates cell cycle progression and induces cellular quiescence by controlling approximately one thousand target genes.
  • Dysregulation of the cell cycle is a hallmark of cancer, making the DREAM complex a potential factor in tumorigenesis.

Purpose of the Study:

  • To review current understanding of the DREAM complex's function in cancer.
  • To identify specific cancer types affected by DREAM complex alterations.
  • To explore therapeutic strategies targeting the DREAM complex for cancer treatment.

Main Methods:

  • Literature review of recent advances in DREAM complex research.
  • Analysis of the DREAM complex's role in cell cycle regulation and cancer.
  • Exploration of potential therapeutic interventions targeting the DREAM complex.

Main Results:

  • The DREAM complex plays a significant role in cell cycle control and quiescence.
  • Its involvement in various cancer types is an area of active investigation.
  • Targeting the DREAM complex presents a potential, yet underexplored, therapeutic avenue.

Conclusions:

  • Further research into the DREAM complex's specific roles in different cancers is warranted.
  • Developing therapies that target the DREAM complex may offer novel cancer treatment strategies.
  • Understanding the DREAM complex is crucial for advancing cancer therapeutics.
Keywords:
DREAM complexcancer cell quiescencecancer therapycell cycle regulationtargeted therapy

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