Related Experiment Video

Updated: Jun 3, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.5K

Dual Roles of miR-10a-5p and miR-10b-5p as Tumor Suppressors and Oncogenes in Diverse Cancers

Rajan Singh1, Se Eun Ha1, Tae Yang Yu1,2

  • 1Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.

International Journal of Molecular Sciences
|January 11, 2025
PubMed

Insights

MicroRNAs (miRNAs) like miR-10a/b-5p have dual roles in cancer, acting as tumor suppressors or oncogenes. Understanding these roles is key for developing novel miRNA-based cancer therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Cancer is a genetic disorder involving non-coding RNAs, including microRNAs (miRNAs).
  • miRNAs regulate cancer development, acting as tumor suppressors or oncogenes.
  • The miR-10 family, specifically miR-10a-5p and miR-10b-5p (miR-10a/b-5p), is implicated in cancer progression.

Purpose of the Study:

  • To review the dual roles of miR-10a/b-5p in various cancers.
  • To examine the molecular and cellular mechanisms underlying their function.
  • To discuss their potential as therapeutic targets for cancer treatment.

Main Methods:

  • Literature review of studies on miR-10a/b-5p in cancer.
  • Analysis of molecular and cellular mechanisms.
  • Evaluation of impact on the tumor microenvironment.

Main Results:

  • miR-10a/b-5p can function as both tumor suppressors and oncogenes.
  • Their roles vary depending on the cancer type and target genes.
  • These miRNAs influence key cancer processes like initiation, promotion, and metastasis.

Conclusions:

  • miR-10a/b-5p exhibit context-dependent functions in cancer.
  • Targeting miR-10a/b-5p offers potential for innovative cancer therapies.
  • Further research is needed to fully elucidate their therapeutic applications.
Keywords:
cancermiR-10amiR-10bmicroRNAsoncogenetherapeuticstumor suppressor

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