Related Experiment Video
Updated: Jun 3, 2025
07:20
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
36.3K
Emerging Biomarkers and Determinants of Lipoprotein Profiles to Predict CVD Risk: Implications for Precision
Catherine J Andersen1, Maria Luz Fernandez1,2
1Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Nutrients
|January 11, 2025
Summary
Biomarkers for lipoprotein profiles aid in predicting cardiovascular disease (CVD) risk and guiding precision nutrition. Understanding these biomarkers and their determinants is crucial for effective CVD prevention strategies.
Area of Science:
- Biomarkers and precision nutrition for chronic disease management.
- Cardiovascular disease (CVD) risk assessment and prediction.
Background:
- Cardiovascular disease (CVD) remains a leading global cause of mortality.
- Dyslipidemias and lipoprotein profiles are key indicators of CVD risk.
- Precision nutrition interventions require effective biomarkers for design and evaluation.
Purpose of the Study:
- To comprehensively review biomarkers and emerging approaches for characterizing lipoprotein profiles.
- To evaluate lipoprotein profiles as predictive tools for assessing CVD risk.
- To discuss determinants influencing lipoprotein profiles and interindividual responses to nutrition.
Main Methods:
- Evaluation of traditional clinical lipid panels.
- Assessment of lipoprotein efflux capacity, inflammatory, and antioxidant activity.
- Omics-based characterization of lipoprotein composition and metabolism regulators.
Main Results:
- Lipoprotein profiles, including traditional lipids and functional measures, are strong CVD risk predictors.
- Emerging omics approaches offer deeper insights into lipoprotein metabolism.
- Demographic, genetic, metagenomic, and lifestyle factors significantly influence lipoprotein profiles.
Conclusions:
- Biomarkers of lipoprotein profiles are essential for CVD risk prediction and precision nutrition.
- A holistic understanding of lipoprotein determinants is necessary for personalized CVD prevention.
- Further research into emerging biomarkers and their interplay with lifestyle factors is warranted.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
56
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
56
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
130
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
130
01:31Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
01:29Cholesterol: Significance and Regulation
500
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
500
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
96
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
96
01:18Lipids: Dietary Sources and Requirements
681
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
681