Effect of Proanthocyanidins from Grape Seed Extract on Benign Prostatic Hyperplasia

Area of Science:

• Urology
• Natural Products Chemistry
• Pharmacology

Background:

• Benign prostatic hyperplasia (BPH) is a common condition in men over 40.
• Proanthocyanidins (PACs) show potential in treating prostate health issues.
• Grape seed extract (GSE) is rich in PACs, with potential therapeutic applications.

Purpose of the Study:

• To compare the bioactivities of GSE and alkaline-processed GSE (ATGSE) in an animal model of BPH.
• To evaluate the efficacy of oligomeric PACs in ATGSE against BPH.
• To assess the impact of GSE and ATGSE on prostate and seminal vesicle health.

Main Methods:

• An animal model of BPH was induced using testosterone injections.
• Animals were treated with varying doses of GSE and ATGSE via oral gavage.
• Hematological, biochemical, and tissue analyses were conducted after 4 weeks.

Main Results:

• ATGSE significantly reduced prostate and seminal vesicle weight more effectively than GSE.
• ATGSE demonstrated superior efficacy in lowering prostate-specific antigen (PSA) levels.
• ATGSE significantly decreased pro-inflammatory cyto-chemokines in prostate and seminal vesicles.

Conclusions:

• ATGSE is a more potent therapeutic agent for BPH than GSE.
• ATGSE shows promise as a nutraceutical or functional food for managing BPH.
• Further clinical applications of ATGSE for prostate health are warranted.