Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

311
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
311
Anatomy of the Intestines01:23

Anatomy of the Intestines

71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

377
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
377
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
Cancer Prevention02:59

Cancer Prevention

6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Microbiota Composition and Plasma Metabolomic Profile Are Associated with Amyloid Pathology and Cognitive Performance in Patients with Mild Cognitive Impairment.

Nutrients·2026
Same author

Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.

European journal of nutrition·2026
Same author

Genetics of cardiovascular disease: genes and polymorphisms in pathways underlying atherosclerosis and clinical events.

Journal of advanced research·2026
Same author

High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

The American journal of clinical nutrition·2026
Same author

<i>NR3C1</i>, <i>LAX1</i>, and <i>RCAN3</i> as Circulating Epigenetic Biomarkers for Prognosis and Chemotherapy Response Prediction in Metastatic Pancreatic Cancer.

MedComm·2026
Same author

Immunogenicity of Hepatitis B Virus Vaccination in Relapsing-Remitting Multiple Sclerosis Patients Under Immunocompromising Treatment.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jun 3, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.8K

Gut Microbiota Interacts with Dietary Habits in Screenings for Early Detection of Colorectal Cancer.

Ana Vega-Rojas1,2,3,4, Carmen Haro5, Helena Molina-Abril6

  • 1Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University Hospital, 14004 Cordoba, Spain.

Nutrients
|January 11, 2025
PubMed
Summary

Combining gut microbiota analysis with dietary habits shows promise for early colorectal cancer (CRC) detection. This approach can improve screening programs by identifying individuals with CRC-related lesions.

Keywords:
colorectal cancerdietary habitsearly diagnosisgut microbiomerandom forestscreening program

More Related Videos

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

6.9K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

2.7K

Related Experiment Videos

Last Updated: Jun 3, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.8K
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

6.9K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

2.7K

Area of Science:

  • Microbiome research
  • Gastroenterology
  • Cancer screening

Background:

  • Gut microbiota composition is linked to nutrient interactions and may serve as a biomarker for colorectal cancer (CRC).
  • Early detection of CRC through screening programs can significantly improve patient outcomes.

Purpose of the Study:

  • To evaluate the potential of gut microbiota and dietary habits for early detection of CRC-related pathological findings.
  • To assess the combined predictive power of microbial signatures and dietary patterns in CRC screening.

Main Methods:

  • Analysis of gut microbiota using 16S metagenomic sequencing in 152 subjects undergoing colonoscopy.
  • Development of classification models using the Random Forest (RF) algorithm in R.
  • Comparison of model performance using gut microbiota data, dietary habits data, and a combined approach.

Main Results:

  • The combined model of gut microbiota and dietary habits achieved an area under the curve (AUC) of 0.804, outperforming models using either data source alone (AUC 0.790 for microbiota, 0.710 for diet).
  • Specific microbial taxa (e.g., *Suterella*, *Oscillospirales*) and dietary factors (fruit/vegetable intake, beverage consumption) were identified as key discriminators.
  • RF classifier models demonstrated the potential of these factors in distinguishing individuals with CRC-related lesions from those without.

Conclusions:

  • The interplay between gut microbiota and dietary habits is crucial for developing microbial signatures for CRC detection.
  • Integrating gut microbiota signatures with dietary information can enhance the effectiveness of screening programs for early CRC identification.