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Ibuprofen: plasma concentrations in man.

G M Janssen, J F Venema

    The Journal of International Medical Research
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study found that taking 600 mg ibuprofen tablets multiple times daily did not lead to drug accumulation in plasma. Ibuprofen dosing frequency did not significantly alter peak plasma levels or cause adverse effects in healthy individuals.

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    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology

    Background:

    • Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
    • Understanding ibuprofen's pharmacokinetic profile is crucial for optimizing therapeutic efficacy and safety.

    Purpose of the Study:

    • To evaluate ibuprofen plasma levels and potential accumulation with different dosing frequencies.
    • To assess the safety and tolerability of varied ibuprofen dosage regimens.

    Main Methods:

    • A crossover study involving five healthy subjects.
    • Administration of 600 mg ibuprofen tablets twice, three, and four times daily.
    • Measurement of plasma ibuprofen concentrations at specified intervals.

    Main Results:

    • Peak plasma ibuprofen levels were achieved approximately 1 hour after the first dose.

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  • Repeated dosing (twice, thrice, or four times daily) did not result in significant drug accumulation.
  • Observed peak plasma concentrations remained within a similar range across different dosing frequencies.
  • No adverse side-effects were reported during the study.

    • Conclusions:

    • Ibuprofen (600 mg) does not appear to accumulate in plasma with twice, thrice, or four times daily dosing in healthy subjects.
    • The dosing frequency studied did not lead to increased plasma concentrations or adverse events.
    • These findings support the predictable pharmacokinetic behavior of ibuprofen within the tested regimens.