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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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Correction: Pramesthi et al. Evaluating the Impact of Indonesia's National School Feeding Program (ProGAS) on Children's Nutrition and Learning Environment: A Mixed-Methods Approach. <i>Nutrients</i> 2025, <i>17</i>, 3575.

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Correction: Huang et al. Correlation Study Between Dietary Behaviors, Lifestyle, and Psychological Problems in Chinese Children Aged 3-7. <i>Nutrients</i> 2025, <i>17</i>, 176.

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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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A Randomized Pilot Study of Time-Restricted Eating Shows Minimal Microbiome Changes.

Abigail J Johnson1, Alison Alvear2, Dan Knights3

  • 1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.

Nutrients
|January 11, 2025
PubMed
Summary
This summary is machine-generated.

Time-restricted eating (TRE) did not significantly alter gut microbiome composition in a small study. Further research with larger sample sizes is needed to confirm these findings on TRE and the gut microbiome.

Keywords:
fastinggut microbiomeobesitytime-restricted eatingweight loss

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Area of Science:

  • Human microbiome research
  • Metabolic health and obesity interventions

Background:

  • Time-restricted eating (TRE) is an emerging strategy for obesity management.
  • Limited data exists on TRE's impact on the human gut microbiome composition.

Purpose of the Study:

  • To characterize changes in gut microbiome composition before and after a TRE intervention in human participants.
  • To conduct a secondary analysis of a clinical trial on TRE's effects.

Main Methods:

  • Shotgun metagenomic sequencing of stool samples collected at baseline and post-intervention.
  • Comparison of microbiome community composition using alpha and beta diversity metrics.
  • Analysis of data from a subset of participants in a 12-week randomized controlled trial.

Main Results:

  • No significant differences in alpha or beta diversity were observed between the TRE and control groups.
  • The TRE group successfully reduced their eating window, leading to weight and visceral fat loss.
  • The study was limited by a small sample size (n=5 for full analysis) and short duration.

Conclusions:

  • TRE intervention did not significantly alter gut microbiome composition or diversity in this study.
  • Larger sample sizes, longer durations, and detailed dietary data are necessary for future TRE and microbiome research.
  • The relationship between TRE and gut microbiome dynamics requires further investigation.