Polycystic Ovary Syndrome and Eating Disorders-A Literature Review

Area of Science:

• Endocrinology
• Reproductive Health
• Psychiatry

Background:

• Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women.
• PCOS is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology.
• It is frequently linked with metabolic dysfunction and psychiatric conditions, notably eating disorders (EDs).

Purpose of the Study:

• To review the roles of key hormones in the pathophysiology of PCOS and associated psychiatric symptoms.
• To explore the bidirectional relationship between PCOS and eating disorders.
• To emphasize the need for a multidisciplinary approach in managing PCOS.

Main Methods:

• Literature review identifying key hormonal factors (serotonin, leptin, insulin, ghrelin, kisspeptin, cortisol).
• Analysis of the impact of these hormones on PCOS pathophysiology and psychiatric comorbidities.
• Examination of the interplay between hormonal imbalances and eating disorders.

Main Results:

• Serotonin deficiency in PCOS is linked to mood and eating disorders.
• Leptin fluctuations affect HPO axis function and fertility.
• Elevated kisspeptin and hyperinsulinemia in PCOS correlate with increased susceptibility to eating disorders.
• Ghrelin and cortisol also play significant roles.

Conclusions:

• Hormonal imbalances in PCOS create a vicious cycle with psychiatric conditions, particularly eating disorders.
• A multidisciplinary treatment approach is essential for effective PCOS management.
• Early screening and personalized interventions are vital for improving outcomes for women with PCOS.