Concurrent Validity Between EQ-5D and HRQ-6D Measures in Patients with Different Primary Diagnoses

Area of Science:

• Health Outcomes Research
• Psychometrics
• Clinical Epidemiology

Background:

• Health-related quality of life (HRQOL) is crucial for patient-centered care.
• The EQ-5D is the established gold standard for HRQOL measurement.
• The HRQ-6D is a novel instrument developed to assess HRQOL.

Purpose of the Study:

• To evaluate the concurrent validity of the HRQ-6D against the EQ-5D.
• To assess HRQ-6D performance across diverse patient populations with distinct primary diagnoses.

Main Methods:

• A cross-sectional study involving 149 patients with heart disease, cancer, depressive disorders, or end-stage renal disease (ESRD).
• Utilized two HRQOL instruments: EQ-5D-3L and the HRQ-6D.
• Data collected from January to May 2023 at a tertiary hospital.

Main Results:

• Most HRQ-6D domains significantly correlated with EQ-5D-3L domains (p < 0.001), controlling for primary diagnosis.
• The HRQ-6D's 'Physical energy' domain showed significant association with EQ-5D-3L's 'Usual activities' (p < 0.001).
• A significant correlation was found between overall HRQ-6D scores and EQ-VAS (coefficient = 0.445, p < 0.001).

Conclusions:

• The HRQ-6D demonstrates strong concurrent validity with the EQ-5D.
• The HRQ-6D is a reliable instrument for measuring patient outcomes.
• Clinicians and researchers can confidently utilize the HRQ-6D in interventional and observational studies.