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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Ovarian Cycle01:27

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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Updated: Jun 3, 2025

Fertility Preservation in Patients with Severe Ovarian Dysfunction
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Non-Male Factor Only-ICSI Can Overcome Oocyte Factor in PCOS Patients.

Yasmin Shibli Abu Raya1, Nardin Aslih1, Yuval Atzmon1

  • 1Gynecological Research Laboratory, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera 3820302, Israel.

Journal of Clinical Medicine
|January 11, 2025
PubMed
Summary
This summary is machine-generated.

Intracytoplasmic sperm injection (ICSI) demonstrated faster embryo development and higher KIDScores compared to in vitro fertilization (IVF). ICSI showed superiority in cases of female factor infertility, particularly in women with PCOS.

Keywords:
ICSIIVFKIDScoresPCOSmorphokineticssibling oocytes

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization

Background:

  • Retrospective study analyzing IVF vs. ICSI techniques.
  • Focus on embryo morphokinetics using time-lapse incubation in fresh cycles.
  • Data collected from 2018-2022.

Purpose of the Study:

  • To evaluate the impact of IVF versus ICSI on embryo development.
  • To compare morphokinetic parameters between the two techniques.
  • To identify specific patient subgroups benefiting from ICSI.

Main Methods:

  • Analysis of 2645 treatment cycles and 11,471 fertilized oocytes.
  • Embryo grouping based on IVF or ICSI treatment.
  • Monitoring embryonic development via time-lapse incubator with day 3 or 5 embryo transfer.

Main Results:

  • ICSI group embryos exhibited faster development and reduced fragmentation.
  • Fewer 2-pronuclear (2PN) oocytes and more discarded embryos observed in ICSI.
  • Sibling oocyte analysis revealed quicker development and higher KIDScores with ICSI.
  • Anovulation and PCOS subgroups showed significant improvement with ICSI.

Conclusions:

  • ICSI is beneficial for women with PCOS undergoing IVF compared to standard IVF.
  • ICSI demonstrates superiority over IVF in cases of female factor infertility.
  • ICSI may positively influence oocyte factors, similar to its established role in male factor infertility.