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Updated: Jun 22, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Network Analysis of Legg-Calve-Perthes Disease and Its Comorbidities

KyeongMi Kim1, Kyung Rae Ko2, Siyoung Yoon3

  • 1Department of Laboratory Medicine, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang 10414, Republic of Korea.

Journal of Clinical Medicine
|January 11, 2025
PubMed

Insights

Network analysis reveals injury-related conditions and congenital hip deformities are significantly associated with Legg-Calvé-Perthes disease (LCPD) in children. This study enhances understanding of LCPD comorbidities.

Area of Science:

  • Pediatric Orthopedics
  • Epidemiology
  • Medical Informatics

Background:

  • Legg-Calvé-Perthes disease (LCPD) involves idiopathic avascular necrosis of the femoral head in children.
  • The precise etiology of LCPD remains elusive, necessitating further investigation into contributing factors.
  • Comorbidity studies offer valuable insights into the complex nature of LCPD.

Purpose of the Study:

  • To conduct a network analysis identifying associations between Legg-Calvé-Perthes disease (LCPD) and its comorbidities.
  • To explore potential etiological links and clinical implications through comorbidity profiling.

Main Methods:

  • Analysis of pediatric patients (≤12 years) diagnosed with LCPD using ICD-10 codes from a national health insurance database (2002-2015).
  • Propensity score matching was employed to establish a control group.
  • Network analysis was performed on identified comorbidities, with results visualized using odds ratios.

Main Results:

  • Twenty-three significant disease clusters associated with LCPD were identified.
  • Injury-related disease clusters (ICD-10 codes starting with 'S') were most prevalent.
  • Congenital hip deformities (Q65) exhibited the highest odds ratio, followed by congenital foot deformities (Q66) and other anemia (D64).

Conclusions:

  • Network analysis confirms significant associations between LCPD and various comorbidities.
  • The identified comorbidity network provides a foundation for future research into the pathogenesis and management of LCPD.
  • Understanding these associations may guide diagnostic and therapeutic strategies for pediatric patients with LCPD.

Keywords:
Legg–Calvé–Perthes diseasebig datacomorbiditynetwork analysis

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