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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Decreased Structural Connectivity Between Thalamic Nuclei and Hippocampus in Temporal Lobe Epilepsy-A Diffusion

Mehmet S Yildirim^1,2, Radheshyam Stepponat², Florian Ph S Fischmeister^2,3

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.

European Journal of Neurology

|January 11, 2025

Summary

This summary is machine-generated.

Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) shows reduced anterior thalamic nuclei (ANT) volume and connectivity. These changes correlate with epilepsy duration and seizure frequency, offering insights into treatment strategies.

Keywords:

anterior thalamic nuclei diffusion tensor imaging hippocampal sclerosis structural brain network temporal lobe epilepsy

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Area of Science:

Neuroscience
Epileptology
Radiology

Background:

Temporal lobe epilepsy (TLE) is frequently associated with extratemporal structural abnormalities, notably thalamus atrophy.
Investigating structural connectivity between thalamic nuclei and the hippocampus is crucial for understanding TLE pathophysiology.

Purpose of the Study:

To investigate the structural connectivity between individual thalamic nuclei and the hippocampus in TLE patients using probabilistic tractography.
To correlate structural connectivity and regional volumes with clinical data in TLE.

Main Methods:

36 TLE patients (including TLE with hippocampal sclerosis [TLE-HS] and MRI-negative TLE [TLE-MRneg]) and 18 controls underwent 3 Tesla MRI.
Probabilistic tractography and whole-brain segmentation were used to quantify streamline counts between thalamic nuclei and the hippocampus.
Connectivity strength and regional volumes were correlated with clinical parameters like epilepsy duration and seizure frequency.

Main Results:

TLE-HS patients exhibited significantly decreased ipsilateral thalamus volume, particularly in the anterior thalamic nuclei (ANT), compared to controls.
Reduced ipsilateral connectivity strength between the hippocampus and ANT was observed in TLE-HS.
Decreased ANT connectivity negatively correlated with epilepsy duration and positively with seizure frequency; ANT volume also negatively correlated with epilepsy duration.

Conclusions:

Atrophy and reduced connectivity of the anterior thalamic nuclei (ANT) are characteristic of TLE with hippocampal sclerosis (TLE-HS).
These structural alterations in ANT are linked to epilepsy duration and seizure frequency.
Understanding these network dynamics may improve the management of surgery-resistant epilepsy and patient selection for neurosurgery.