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HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
Published on: July 23, 2016
Vernonolide A, a Sesquiterpene Lactone with a Unique Carbon Skeleton from Vernonia cinerea
Mengke Zhang1, Tamara P Kondratyuk2, Shugeng Cao2
1Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, P. R. China.
Abstract:
A novel sesquiterpene lactone derivative, vernonolide A (1), featuring an unprecedented carbon skeleton, along with its plausible biosynthetic precursor, vercinolide I (2), and eight known sesquiterpene lactones (3-10) were isolated and characterized from the whole plants of Vernonia cinerea (L.). The structures of 1 and 2 were elucidated using nuclear magnetic resonance spectroscopic analysis and calculated and experimental electronic circular dichroism spectra. A plausible biosynthetic pathway for 1 was proposed. Notably, compounds 8 and 10 exhibited significant inhibitory effects on tumor necrosis factor-α-induced nuclear factor-κB activity, with IC50 values of 0.95 and 5.57 μM, respectively.
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