Colonic absorption of 1,2-dimethyl hydrazine (DMH) in the rat

1,2-Dimethyl hydrazine (DMH) is absorbed in the colon by passive diffusion in the 0.1-5.0 mM concentration range. Absorption of DMH is enhanced by both conjugated and unconjugated bile acids. The presence of hydroxy-fatty acids in the colon markedly increased DMH absorption while fatty acids of different chain length did not influence absorption.