Innovative anticancer molecule andrographolide: a concise review of its pharmacological targets

Labdane diterpenoid lactone andrographolide has gained attention in medicinal research due to its potential anticancer properties in terms of suppression of the growth, propagation, and relocation of various types of cancerous cells. The current review provides deep insight into the pharmacological analysis of the anticancer secondary metabolite andrographolide. We have attempted to keep an overview on the interaction of promising drugs like ligand molecule andrographolide with various biological targets. The observation indicates that andrographolide significantly down-regulates the growth of cancer cells through various mechanisms via diminishing inducible nitric oxide synthase (iNOS) expression, attenuating Akt and JNK signalling cascade, inhibiting NF-κB activation, ROS generation in the neoplastic cells etc. This bio-molecule is a potent therapeutic agent that can be applied in treating and preventing inflammatory vascular diseases. This study may be beneficial in the area of drug development research, leading to better management of cancer and many other inflammatory diseases.