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Terpenes from Platycladus orientalis and the evaluation of their potential anti-inflammatory activity
Yi-Fan Xie1, Song-Xue Yang1, Xue-Wen Wu1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Medicine, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Abstract:
Two undescribed compounds, including one monoterpene (1) and one sesquiterpene (2), together with eleven known compounds were isolated from Platycladus orientalis. The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity. The results showed that compounds 5-6, 9 and 12 exhibited NLRP3-inflammasome inhibitory activity.
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