Macrophage membrane-biomimetic ROS-responsive platinum nanozyme clusters for acute kidney injury treatment

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Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
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Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

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Hanzhi Deng1, Ying Qu1, Bingyang Chu1

  • 1Department of Biotherapy and Department of Hematology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Biomaterials
|January 11, 2025
PubMed

Insights

A novel biomimetic nano-system (MM-PtNCs) effectively treats acute kidney injury (AKI) by targeting inflammation and scavenging reactive oxygen species (ROS). This approach reduces kidney damage and prevents progression to chronic kidney disease.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Renal Physiology

Background:

  • Acute kidney injury (AKI) is a prevalent condition with no effective treatments, characterized by rapid loss of kidney function.
  • Oxidative stress and inflammation are key drivers in AKI development and progression.
  • Current therapeutic options for AKI are limited.

Purpose of the Study:

  • To develop and evaluate a novel biomimetic nano-system (MM-PtNCs) for alleviating AKI.
  • To investigate the potential of MM-PtNCs in modulating oxidative stress and inflammation in AKI.
  • To assess the efficacy of MM-PtNCs in preventing AKI progression to chronic kidney disease.

Main Methods:

  • Development of a macrophage membrane (MM)-coated nano-system encapsulating reactive oxygen species (ROS)-responsive platinum nanozyme clusters (PtNCs).
  • Utilizing the targeting and anti-inflammatory properties of macrophage membranes.
  • Employing the ROS-scavenging and catalase-like activity of PtNCs for oxidative stress regulation.
  • Evaluating MM-PtNCs in a mouse model of ischemia/reperfusion-induced AKI.

Main Results:

  • Systemic injection of MM-PtNCs significantly reduced renal damage in a mouse AKI model.
  • MM-PtNCs effectively restored kidney function.
  • The nano-system demonstrated efficacy in preventing the progression of AKI to chronic kidney disease.

Conclusions:

  • MM-PtNCs represent a promising multi-faceted therapeutic strategy for AKI.
  • The biomimetic nano-system effectively targets renal inflammation and mitigates oxidative stress.
  • This approach offers potential for clinical translation in AKI treatment.
Keywords:
Anti-inflammationBiomimetic nano-systemMetal nanozymeROS scavengingRenal ischemia-reperfusion injury

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