Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between preoperative nutritional status and mortality in patients with type B aortic dissection undergoing thoracic endovascular aortic repair: a retrospective cohort study.

Journal of thoracic disease·2026
Same author

Single-cell RNA-seq profiles of colonic intestinal mucosa in IBS-D rats to explore the mechanism of immune barrier regulation in pathogenesis.

Scientific reports·2026
Same author

HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.

bioRxiv : the preprint server for biology·2026
Same author

Determinants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study.

medRxiv : the preprint server for health sciences·2026
Same author

Attaining 19.12% solar cell efficiency for non-fused ring electron acceptors via multi-dimensional charge transport.

Nature communications·2026
Same author

Efficient Deep Learning Models for Predicting Individualized Task Activation From Resting-State Functional Connectivity.

Human brain mapping·2026

Related Experiment Video

Updated: Jun 3, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.0K

Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.

Vaibhav Tripathi1, Ishaan Batta2, Andre Zamani3

  • 1Center for Brain Science and Department of Psychology, Harvard University, Cambridge, Massachusetts; Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|January 11, 2025
PubMed
Summary

The default mode network (DMN) shows promise as a biomarker for cognitive health. Its connectivity patterns can indicate cognitive states and deviations in conditions like Alzheimer's disease and ADHD.

Keywords:
AttentionBrain networksFunctional connectivityMeditationMental healthResting-state fMRI

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.1K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.1K

Related Experiment Videos

Last Updated: Jun 3, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.0K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.1K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.1K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychiatry

Background:

  • The default mode network (DMN) is crucial for self-referential thought, memory, and social cognition.
  • Functional connectivity of the DMN, especially its anticorrelation with frontoparietal networks, is linked to cognitive health.
  • Resting-state fMRI enables large-scale DMN connectivity analysis, supporting biomarker development.

Purpose of the Study:

  • To review the role of DMN connectivity metrics as biomarkers for cognitive states.
  • To investigate DMN deviations in aging and clinical conditions (e.g., Alzheimer's, ADHD).
  • To address the reliability of DMN network estimation and functional connectivity measures.

Main Methods:

  • Review of existing literature on DMN functional connectivity.
  • Analysis of resting-state fMRI data for DMN and frontoparietal network interactions.
  • Exploration of DMN connectivity in various cognitive states and clinical populations.

Main Results:

  • DMN connectivity metrics show potential as biomarkers for attention, mind wandering, and meditation.
  • Altered DMN connectivity is observed in aging and neurodegenerative/psychiatric disorders.
  • Reliability of DMN network estimation is a critical factor for biomarker application.

Conclusions:

  • DMN functional connectivity offers a promising avenue for cognitive health assessment.
  • Standardized connectivity benchmarks are needed for reliable DMN biomarker development.
  • Further research is essential to validate DMN metrics across diverse cognitive and clinical profiles.