[Analysis of pharmaceutical interventions related to outpatient treatment of chronic heart failure]

Our aim was to analyze pharmaceutical interventions related to heart failure (HF) outpatient treatment.

An observationnal study was carried out over 6 months at the Abidjan Institute of Cardiology (ICA). Data were collected using a survey form that focused on therapeutic adherence, drugs related-problems (DRP) and pharmaceutical interventions (PI). DRP and PI coding tool of French Society of Clinical Pharmacy was used. Therapeutic adherence was assessed using the GIRERD tool. Prescription review made by Algorithm of Calop. Clinical, economic and organizational impacts of PI accepted by the physician were rated using the CLEO tool.

Study population had a mean age of 51.4 years. DRP prevalence was 59%. These DRP were essentially adherence problem (43%) and drug-drug interactions (39.7%). The PIs were mainly "optimization of administration methods" (43.6%) and "therapeutic monitoring" (38.1%). The acceptance rate of PIs intended for prescribers was 80.8%. Mainly of these PIs were rated "PI with minor clinical impact" (60.2%), "PI without economic impact" (83.8%) and PI with "positive organizational impact" (63.2%).

DRPs and more specifically adherence problems and drug-drug interactions are common in HF outpatient management. The pharmacist can contribute to improve this care through regular assessment of therapeutic adherence and management of DRPs.