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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Intelligent skin disease prediction system using transfer learning and explainable artificial intelligence.

Sagheer Abbas1, Fahad Ahmed2, Wasim Ahmad Khan3

  • 1Department of Computer Science, Prince Mohammad Bin Fahd University, 34754, Al-Khobar, Dhahran, KSA, Saudi Arabia.

Scientific Reports
|January 11, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a deep learning (DL) model using transfer learning (TL) to accurately identify skin diseases like chickenpox, measles, and monkeypox. Layer-wise relevance propagation (LRP) enhances diagnostic insights from the model.

Keywords:
And layer-wise relevance propagation (LRP)Artificial intelligence (AI)ChickenpoxDeep learning (DL)Explainable artificial intelligence (XAI)Machine learning (ML)MeaslesMonkeypoxTransfer learning (TL)VGG16

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Skin diseases present a global health challenge, requiring laborious diagnostic processes.
  • Accurate identification and prediction of skin conditions are complicated by disease complexity and numerous clinical features.
  • Current diagnostic methods for skin diseases are time-consuming and require extensive clinical and histological data.

Purpose of the Study:

  • To develop a rapid and accurate deep learning model for identifying common skin diseases.
  • To leverage transfer learning for efficient disease prediction using VGG16 architecture.
  • To enhance the interpretability of deep learning models in healthcare using layer-wise relevance propagation (LRP).

Main Methods:

  • A deep learning model utilizing a pre-trained VGG16 for transfer learning was employed.
  • A dataset comprising skin images of chickenpox, measles, monkeypox, and normal skin was curated and split for training and testing.
  • Layer-wise relevance propagation (LRP) was applied to interpret the model's predictions and identify relevant visual features.

Main Results:

  • The VGG16 transfer learning model achieved a testing accuracy of 93.29% in identifying skin diseases.
  • The application of LRP provided relevance scores, highlighting specific visual symptoms crucial for diagnosis.
  • The interpretable results from LRP offer valuable insights to support clinical decision-making.

Conclusions:

  • Deep learning models, particularly VGG16 with transfer learning, show high accuracy in diagnosing skin diseases.
  • Layer-wise relevance propagation (LRP) effectively addresses the 'black box' nature of deep learning, enhancing model transparency.
  • The integration of interpretable AI can significantly aid healthcare professionals in timely and informed diagnosis and treatment of skin conditions.