Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases

Area of Science:

• Cardiovascular Biology
• Cell Death Mechanisms
• Epigenetics

Background:

• Iron is vital for human physiology and involved in numerous biochemical reactions.
• Ferroptosis, a form of iron-dependent regulated cell death, plays a role in various disease pathologies.
• Iron stability in cardiomyocytes is critical for normal cardiac function, and ferroptosis is observed in multiple cardiovascular diseases (CVDs).

Purpose of the Study:

• To review the core mechanisms of ferroptosis in cardiomyocytes.
• To focus on the role of epigenetic regulation and expression of ferroptosis-related factors in CVDs.
• To provide new insights into CVD pathogenesis and inspire targeted clinical interventions.

Main Methods:

• Literature review of ferroptosis mechanisms in cardiovascular disease.
• Analysis of epigenetic regulation's role in ferroptosis-related factors.
• Synthesis of current understanding of ferroptosis in common cardiovascular diseases.

Main Results:

• Ferroptosis is a significant factor in the pathogenesis of cardiovascular diseases.
• Epigenetic modifications and post-translational modifications influence ferroptosis-related factors in cardiomyocytes.
• Iron homeostasis in cardiomyocytes is regulated by these mechanisms and impacts CVD progression.

Conclusions:

• A detailed understanding of the relationship between epigenetic regulation and ferroptosis in CVDs is lacking.
• This review summarizes key mechanisms, highlighting epigenetic regulation of ferroptosis in CVDs.
• Understanding these pathways may lead to novel therapeutic strategies targeting ferroptosis in cardiovascular conditions.