Role of antioxidative stress activity of Fucoxanthin nanoparticle as hepatoprotective in diabetic rats

This study attempts to prove that the antioxidant effect of fucoxanthin nanoparticles can prevent streptozotocin-induced rat liver damage. Fucoxanthin nanoparticles are synthesized using the high-energy ball milling method. Dynamic Light Scattering (DLS) was then used to describe the sizes of the fucoxanthin nanoparticles. Each of the five groups involved in the research had an average of eight rats. Distilled water was given to the rats in the control group whereas Streptozotocin (STZ) was given to the diabetic group. Additionally, streptozotocin and fucoxanthin administration were performed as the fucoxanthin group. The administration of fucoxanthin nanoparticles caused a significant decline in the levels of the enzymes ALT, AST and ALP in the blood and MDA in the liver tissue of diabetic rats. Furthermore, as compared to the group of diabetic rats, the fucoxanthin nanoparticles treatment produced a significant rise in SOD and GPx levels. These effects directly can prevent histological abnormalities, notably fatty degeneration, and necrosis, in diabetic rats. The findings of this research suggest that fucoxanthin nanoparticles exhibited significant antioxidant activity in STZ-induced diabetic rats. The antioxidant activity of fucoxanthin nanoparticles potential to prevent diabetes complications such as hepatopathy.