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Updated: Jun 3, 2025

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Recent advances in the dual effects of activin A on tumors
Boyang Liu1, Linjing Zhu2, Linfang Bian3
1Department of Genetics, College of Basic Medical Sciences, Jilin University, Jilin, Changchun, 130021, PR China; Department of Scientific Research, Jilin Jianzhu University, Jilin, Changchun, 130118, PR China.
Abstract:
Activin A, a gonadal protein, not only stimulates the pituitary to secrete follicle-stimulating hormone (FSH) but also plays a crucial role in regulating various cell behaviors, such as cell proliferation, differentiation, apoptosis, migration, and invasion. Studies have shown an association between activin A expression and tumor progression, highlighting its dual role in cancer. Similar to transforming growth factor-beta (TGF-β), activin A can have both pro-tumor and anti-tumor effects, for instance, it inhibits the migration of lung adenocarcinoma cells, while promotes the migration of triple-negative breast cancer cells. Therefore, activin A exerts context-dependent effects on different tumor cells. This review explores the biological functions of activin A in tumor progression and treatment, focusing on its influence on tumor cell proliferation, apoptosis, and metastasis. The aim is to offer insights and potential directions for future clinical cancer treatments.
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