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Updated: Jun 3, 2025
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
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High-throughput hit identification with acoustic ejection mass spectrometry
Xiujuan Wen1, David G McLaren1
1Merck & Co., Inc., Rahway, NJ, USA.
SLAS Technology
|January 12, 2025
Summary
This review covers advancements in Acoustic Emission Monitoring Systems (AEMS) for drug discovery. AEMS improve the quality and efficiency of label-free High-Throughput Screening (HTS) for identifying drug candidates.
Area of Science:
- Biochemistry
- Pharmacology
- Analytical Chemistry
Background:
- High-Throughput Screening (HTS) is crucial for drug discovery.
- Label-free screening methods offer advantages over traditional assays.
- Acoustic Emission Monitoring Systems (AEMS) are emerging technologies in this field.
Purpose of the Study:
- To review recent developments in AEMS for drug discovery.
- To highlight AEMS' potential in label-free High-Throughput Screening (HTS).
- To discuss future advancements and applications of AEMS.
Main Methods:
- Literature review of recent AEMS developments.
- Analysis of AEMS applications in label-free HTS.
- Discussion of emerging trends and future prospects.
Main Results:
- AEMS show significant potential to improve HTS quality and efficiency.
- Recent advancements enhance the capabilities of AEMS for hit identification.
- Label-free HTS using AEMS offers a promising approach.
Conclusions:
- AEMS are increasingly valuable tools in modern drug discovery.
- Further advancements will likely expand the role of AEMS in pharmaceutical research.
- AEMS contribute to more efficient and effective identification of drug leads.
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