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Updated: Jun 3, 2025

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

Published on: November 24, 2016

A wearable electrochemical sensor utilizing multifunctional hydrogel for antifouling ascorbic acid quantification in

Zhen Wei¹, Yanxin Li¹, Shuyue Guo¹

¹Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Analytica Chimica Acta

|January 12, 2025

Summary

This study presents a new wearable sensor that uses an advanced hydrogel to detect ascorbic acid (AA) in sweat, overcoming biofouling issues for reliable health monitoring.

Keywords:

Antifouling Ascorbic acid Multifunctional hydrogel Sweat Wearable sensor

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Area of Science:

Biomedical Engineering
Materials Science
Analytical Chemistry

Background:

Wearable sensors for health monitoring are crucial but often compromised by biofouling in real sweat.
Existing electrochemical sensors face performance degradation due to biofouling, limiting their practical application.

Purpose of the Study:

To develop a novel, wearable, antifouling electrochemical sensor for accurate detection of disease markers in human sweat.
To enhance sensor performance and durability in real sweat conditions using a multifunctional hydrogel.

Main Methods:

Fabrication of a polyethylene glycol (PEG)-sulfobetaine methacrylate (SBMA) hydrogel with enhanced antifouling and mechanical properties.
Integration of a silver nanoparticles-molybdenum disulfide (AgNPs-MoS2) composite into the hydrogel to improve catalytic activity for ascorbic acid (AA) detection.
Electrochemical analysis of the sensor's performance in real sweat, assessing interference and reliability.

Main Results:

The developed PEG-SBMA hydrogel exhibits superior antifouling and mechanical characteristics.
The AgNPs-MoS2 composite significantly boosts the sensor's catalytic efficiency for AA detection.
The wearable sensor demonstrated reliable AA detection in real sweat with minimal interference, showcasing practical applicability.

Conclusions:

The novel multifunctional hydrogel-based wearable sensor effectively overcomes biofouling challenges in sweat analysis.
This technology offers a robust platform for non-invasive health monitoring and personalized healthcare through advanced wearable diagnostics.