Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.

Isotopes and Radioisotopes

Isotopes and Radioisotopes

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Application and Research Advances of PET Molecular Imaging in Immune Checkpoint Inhibitor-Associated Myocarditis.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2026

Same author

Preclinical Evaluation of <sup>177</sup>Lu-Labeled Anti-CLDN18.2 VHH-Fc for Radioimmunotherapy in Gastric Cancer.

Molecular pharmaceutics·2026

Same author

Identifing two distinct cortical progression subtypes of Parkinson's disease through multimodal neuroimaging.

European journal of nuclear medicine and molecular imaging·2026

Same author

Development and Evaluation of an Albumin-Binding GPC3-Targeting Peptide for PET Imaging of Hepatocellular Carcinoma.

Molecular pharmaceutics·2026

Same author

CD70-targeted platform for diagnosing and treating multiple myeloma.

Journal for immunotherapy of cancer·2026

Same author

Cascaded deep learning enables multimodal brain PET spatial normalization and quantification for Alzheimer's disease.

NeuroImage·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2025

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Published on: April 6, 2015

Trends in nanobody radiotheranostics.

Xingru Long^1,2,3, Sixuan Cheng^1,2,3, Xiaoli Lan^4,5,6

¹Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan, Hubei, 430022, China.

European Journal of Nuclear Medicine and Molecular Imaging

|January 12, 2025

Summary

Nanobody-based nuclear medicine shows promise for precision medicine and cancer diagnosis. Molecular imaging helps optimize nanobodies for better cancer treatment efficacy.

Keywords:

Cancer theranostics Molecular imaging Nanobody Nuclear medicine Precision medicine

More Related Videos

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of ⁶⁸Ga-Labelled Nano Molecules

Published on: October 4, 2024

Related Experiment Videos

Last Updated: Jun 3, 2025

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Published on: April 6, 2015

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of ⁶⁸Ga-Labelled Nano Molecules

Published on: October 4, 2024

Area of Science:

Nuclear medicine
Precision medicine
Molecular imaging

Background:

Nanobodies are small antibody fragments with specific binding affinity.
Nanobody-based nuclear medicine holds significant potential for precision medicine.
Preclinical and clinical studies support nanobody applications.

Purpose of the Study:

To review clinical results of nanobody-based molecular imaging in cancer diagnosis.
To highlight the role of molecular imaging in optimizing nanobody pharmacokinetics and pharmacodynamics.
To discuss the future therapeutic potential of nanobodies in cancer treatment.

Main Methods:

Review of clinical results demonstrating nanobody-based molecular imaging benefits.
Analysis of pharmacokinetic and pharmacodynamic profiles of nanobodies.
Evaluation of molecular imaging as a tool for nanobody optimization.

Main Results:

Nanobody-based molecular imaging exemplifies benefits in cancer diagnosis.
Suboptimal biodistribution patterns of nanobodies have been observed.
Collaborative efforts are refining nanobody profiles for improved efficacy.

Conclusions:

Nanobody-based molecular imaging is crucial for cancer diagnosis.
Molecular imaging is essential for evaluating and optimizing nanobodies.
Nanobodies offer expanding therapeutic potential for future cancer treatment.