Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps
Mehmet Emre Sivrice1, Vural Akın2, Hasan Yasan1
1Süleyman Demirel University Faculty of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, Isparta, Türkiye.
Turkish Archives of Otorhinolaryngology
|January 13, 2025
Summary
The angiotensin-converting enzyme (ACE) insertion/deletion gene polymorphism is linked to chronic rhinosinusitis (CRS). Individuals with the deletion-deletion genotype and D allele face a higher CRS risk, potentially due to elevated ACE levels.
Area of Science:
- Genetics
- Immunology
- Otolaryngology
Background:
- Inflammatory processes are implicated in the development of chronic rhinosinusitis (CRS).
- Gene polymorphisms are frequently associated with inflammatory conditions.
- The role of specific gene variations in CRS pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the association between the angiotensin-converting enzyme (ACE) insertion/deletion gene polymorphism and CRS.
- To determine if ACE gene variations influence CRS susceptibility.
Main Methods:
- A case-control study involving 52 CRS patients with nasal polyps and 139 controls.
- Genotyping for ACE insertion/deletion polymorphism, including genotype and allele frequencies.
- Statistical comparison of genetic distributions between CRS patients and controls.
Main Results:
- Significant differences in genotype (p=0.015) and allele (p=0.003) distributions of the ACE insertion/deletion polymorphism were observed between CRS patients and controls.
- No significant association was found between ACE genotype distribution and NSAID allergy, asthma, or NSAID-exacerbated respiratory disease in CRS patients.
Conclusions:
- The deletion-deletion genotype and D allele of the ACE insertion/deletion gene polymorphism are associated with an increased risk of CRS.
- Elevated angiotensin-converting enzyme levels may contribute to this increased risk in susceptible individuals.
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