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Updated: Jun 3, 2025

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Completely preorganized bis-lactam-1,10-phenanthroline ligands with high stability for efficient separation of
Fengxin Gao1, Xiaocheng Xu1, Xiaofan Yang1
1College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China. xiaoc@zju.edu.cn.
Abstract:
N,O-Heterocyclic ligands such as 2,9-diamide-1,10-phenanthroline dicarboxamide (DAPhen) and bis-lactam-1,10-phenanthroline (BLPhen) exhibit excellent separation performance for Am(III) and Eu(III) in high-level liquid waste. However, DAPhen-based ligands show poor extraction capacity, and BLPhen ligands suffer from decomposition in acidic solutions, which hinders their application in practical separation processes. To develop ligands with superior performance, two new completely preorganized and highly stabilized bis-lactam-1,10-phenanthroline (BLPhen) ligands with varying alkyl chain lengths were synthesized, demonstrating exceptional extraction and separation of Am(III) from Eu(III) with maximum separation factors of 68 and 53, respectively. DFT calculations and various analytical techniques confirmed that the ligands form 1 : 1 complexes with metal ions, with stronger bonding interactions for Am(III), highlighting their potential for spent nuclear fuel processing.
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