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Updated: Jun 3, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
Biophysical interactions between self-sufficient cytochrome P450 from Tepidiphilus thermophilus and ilaprazole
Jaejeong You1, Yunha Hwang1, Yeon-Ju Jeong2
1Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea. slee026@jbnu.ac.kr.
None:
Proton pump inhibitors (PPIs), metabolized by cytochrome P450 (P450) enzymes, are widely used to inhibit gastric acid secretion. This study investigated CYP116B46, a self-sufficient monooxygenase with a reductase domain, to elucidate its interaction with ilaprazole, a PPI. Binding assays and docking simulations indicate that CYP116B46 serves as a suitable model for studying PPI metabolism.
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